How duplicate genes provide genetic robustness remains an unresolved question.We have examined the duplicated histone deacetylases Sir2p and Hst1p in Saccharomyces cerevisiae and find that these paralogs with non-overlapping functions can provide genetic robustness against null mutations through a substitution mechanism.Hst1p is an NAD(+)-dependent
The Doctor-Writer and the Boundaries of Literariness: The Case of Dannie Abse
This humboldt cider cherry article explores the complex intersections between the roles of physician and writer, focusing on the interpretive challenges inherent in this twofold identity.The works of Dannie Abse (1923-2014), a Welsh-Jewish writer and chest physician, serve as an ideal case study to explore these epistemological tensions and examine
The Importance of Integrating Clinical Relevance and Statistical Significance in the Assessment of Quality of Care--Illustrated Using the Swedish Stroke Register.
When profiling hospital performance, quality inicators are commonly evaluated through hospital-specific adjusted means with confidence intervals.When identifying deviations from a norm, large hospitals can have statistically significant results even for clinically irrelevant deviations while important deviations in small hospitals can remain undisc